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Updated: Aug 26, 2025

Mouse In Vivo Placental Targeted CRISPR Manipulation
Published on: April 14, 2023
Regulatory role of JMJD6 in placental development
Xiaoli Shen1, Christian De Geyter2, Hong Zhang3
1Chongqing Reproductive and Genetics Institute, Chongqing Health Center for Women and Children; Women and Children's Hospital of Chongqing Medical University, Chongqing, PR China.
Abstract:
Correct placental development and function are critical to both the mother's and the foetus' health during pregnancy. Placental function depends on the correct development of the vascular network, which requires proper angiogenesis. Impaired angiogenesis in the placenta can induce foetal growth restriction, preeclampsia, and even foetal death. Placental angiogenesis is finely controlled by ubiquitous and pregnancy-specific angiogenic factors. Jumonji domain-containing protein 6 (JMJD6) is a Fe (II)- and 2-oxoglutarate (2OG)-dependent oxygenase that catalyses arginine demethylation and lysine hydroxylation of histone and non-histone peptides. JMJD6 has been implicated in embryonic development, cellular proliferation and migration, self-tolerance induction in the thymus, and adipocyte differentiation. In this review we present JMJD6's structure and activity, as well as its role in angiogenesis, oxygen sensing, and adverse pregnancy outcomes related to placental development. Understanding the interaction between JMJD6 and other placental factors may identify potential therapeutic targets for correcting abnormal placental angiogenesis and function.
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