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Updated: May 11, 2026

Free-form Light Actuators — Fabrication and Control of Actuation in Microscopic Scale

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Published on: May 25, 2016

Light-Responsive Molecular Release from Cubosomes Using Swell-Squeeze Lattice Control.

Beatrice E Jones^1,2, Elaine A Kelly¹, Nathan Cowieson²

¹Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge CB3 0FS, United Kingdom.

Journal of the American Chemical Society

|October 12, 2022

Summary

We developed light-responsive cubosomes using photoswitchable amphiphiles for controlled drug delivery. UV light triggers structural changes, enabling on-demand release of entrapped molecules.

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Novel Techniques for Observing Structural Dynamics of Photoresponsive Liquid Crystals

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Novel Techniques for Observing Structural Dynamics of Photoresponsive Liquid Crystals

Novel Techniques for Observing Structural Dynamics of Photoresponsive Liquid Crystals

Published on: May 29, 2018

Area of Science:

Materials Science
Nanotechnology
Biophysics

Background:

Stimuli-responsive materials are key for advanced controlled delivery systems.
Lyotropic liquid crystals (LLCs) offer structured matrices for entrapping molecules and forming dispersions.
Current delivery systems lack precise external control over release mechanisms.

Purpose of the Study:

To create light-responsive cubic LLC dispersions (cubosomes) for controlled release applications.
To utilize photoswitchable amphiphiles for external control over cubosome structure.
To demonstrate on-demand release of guest molecules triggered by light.

Main Methods:

Incorporation of azobenzene photosurfactants (AzoPS) into monoolein-water systems to form LLC phases.
Homogenization of LLC phases to create cubosome dispersions (∼200 nm).
Characterization using small-angle X-ray scattering and cryo-transmission electron microscopy.
UV irradiation to induce AzoPS isomerization and observe structural changes.

Main Results:

Successfully formed light-responsive cubosomes with internal cubic phases.
Increasing AzoPS concentration tuned the cubic lattice swelling.
UV irradiation caused rapid isomerization of AzoPS, leading to lattice squeezing.
Demonstrated phototriggerable release of Nile Red guest molecules within minutes.

Conclusions:

Developed the first light-responsive cubosome system using photoswitchable amphiphiles.
Light-induced structural changes in cubosomes enable on-demand release of entrapped molecules.
These light-responsive cubosomes hold significant potential for next-generation nanodelivery systems.