Compounds with antibacterial and antioxidant activities from Cadia purpurea

Five compounds 1-5 were reported from leaves and roots of Cadia purpurea herein. 2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-17-(1-hydroxypent-4-en-2-yl)-10,13-dimethyl-1H-cyclopenta[a]phenanthren-3-ol (1), apigenin-7-O-rhaminoglucoside (2) and 13-O-pyrrolecarboxyl lupanine (3) were isolated from chloroform and methanol leaves extracts. And 5-((trihydro-2-oxy-4-(hydroxymethyl)-5-(3-hydroxyphenyl)furan-3yl)methyl)benzene-1,2,3,4-tetraol (4) and bis(2-hydroxybutyl) phthalate (5) were isolated from the chloroform: methanol (1:1) roots extract. The structures of the compounds were characterized using NMR, IR and GC/MS spectroscopic data. In vitro antibacterial and antioxidant activities of leaves extracts and compounds 1, 2, 4, and 5 were also evaluated. The present findings disclosed that tested compound isolates and extracts showed dose-dependent antibacterial and antioxidant activities. The molecular docking result indicates that isolated compounds show no violation of the Lipinski's rule of five. Compounds 1, 2, 4, and 5 were reported herein for the first time from the leaves and roots of C. purpurea. Further biochemical investigation on whole parts of the plant may uncover additional chemical entities with better biological activities.