Related Experiment Video

Updated: Jul 13, 2026

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue
10:18

Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue

Published on: October 29, 2012

45.0K

Invasive Streptococcus Gallolyticus Infections in Infants At Texas Children's Hospital: A 9-Year Retrospective Review

Marisa Orbea1, Nilesh Desai2, Catherine Foster1

  • 1From the Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine and Texas Children's Hospital.

The Pediatric Infectious Disease Journal
|October 12, 2022
PubMed

Insights

Streptococcus gallolyticus subsp. pasteurianus can cause serious infections like sepsis and meningitis in infants. Early treatment led to favorable outcomes, but some strains showed penicillin resistance, underscoring the need for susceptibility testing.

Area of Science:

  • Pediatric Infectious Diseases
  • Neonatal Microbiology
  • Bacterial Pathogenesis

Background:

  • Streptococcus gallolyticus subsp. pasteurianus is an uncommon cause of invasive infections in neonates.
  • Infections can manifest as bacteremia, sepsis, and meningitis, posing significant risks to infants.

Purpose of the Study:

  • To describe the clinical presentation, treatment, and outcomes of infants with S. gallolyticus subsp. pasteurianus infections.
  • To assess the antimicrobial susceptibility patterns of S. gallolyticus subsp. pasteurianus isolates in this pediatric population.

Main Methods:

  • Retrospective case series analysis of 15 infants diagnosed with S. gallolyticus subsp. pasteurianus bacteremia and/or meningitis.
  • Review of clinical data, treatment regimens, neuroimaging results, and antimicrobial susceptibility testing (AST) data.

Main Results:

  • Fifteen infants with S. gallolyticus subsp. pasteurianus infections were identified.
  • Clinical courses were generally favorable, with limited neuroimaging abnormalities observed.
  • A significant proportion (one-third) of isolates exhibited reduced susceptibility to penicillin.

Conclusions:

  • S. gallolyticus subsp. pasteurianus infections in infants, while unusual, can be managed effectively with appropriate antimicrobial therapy.
  • The emergence of reduced penicillin susceptibility highlights the critical need for routine antimicrobial susceptibility testing in managing infant meningitis and sepsis caused by this pathogen.

More Related Videos

Visualization of the Immunological Synapse by Dual Color Time-gated Stimulated Emission Depletion STED Nanoscopy10:00

Visualization of the Immunological Synapse by Dual Color Time-gated Stimulated Emission Depletion STED Nanoscopy

Published on: March 24, 2014

78.2K
Implantation of Total Artificial Heart in Congenital Heart Disease07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

24.7K

Related Concept Videos

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...