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What is the importance of difference in LCM strategy in drug development? - Learnings from Keytruda and Opdivo

Kota Kodama1, Arisa Djurian2, Yeongjoo Lim3

  • 1Graduate School of Technology Management, Ritsumeikan University, Osaka 567-8570, Japan; Center for Research and Education on Drug Discovery, The Graduate School of Pharmaceutical Sciences in Hokkaido University, Sapporo 060-0812, Japan.

Drug Discovery Today
|October 12, 2022
PubMed

Insights

Keytruda and Opdivo, leading immune checkpoint inhibitors for cancer, show differing commercial success. Strategic inter-organizational deals and drug development drive these sales differences.

Area of Science:

  • Oncology
  • Immunotherapy
  • Pharmaceutical Business

Background:

  • Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment.
  • Six ICIs were approved by February 2022, with Keytruda and Opdivo dominating global sales.
  • Understanding commercial success drivers is crucial for ICI market strategy.

Approach:

  • Analyzed inter-organizational deals for Keytruda and Opdivo since their 2014 launch.
  • Correlated cumulative indications with product sales trends.
  • Examined differences in life cycle management and drug development strategies.

Key Points:

  • Both Keytruda and Opdivo demonstrated a link between the number of approved indications and sales.
  • Sales trends diverged between 2017 and 2018.
  • Distinct strategies in inter-organizational deals and drug development influenced commercial outcomes.

Conclusions:

  • Differences in commercial success between Keytruda and Opdivo stem from varied strategic approaches.
  • Effective life cycle management via inter-organizational deals is key to maximizing drug sales.
  • Tailored drug development strategies are essential for competitive advantage in the ICI market.
Keywords:
Combination therapyInter-organizational transactionKeytrudaOpdivoiPD-(L)1 inhibitors

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