Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

639
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
639
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

4.5K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
4.5K
Cancer Therapies02:49

Cancer Therapies

7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
Cancer Vaccines01:30

Cancer Vaccines

488
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
488
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel role of Wip1 in p53-mediated cell homeostasis under non-stress conditions.

Cell cycle (Georgetown, Tex.)·2011
Same author

Globular adiponectin protects human umbilical vein endothelial cells against apoptosis through adiponectin receptor 1/adenosine monophosphate-activated protein kinase pathway.

Chinese medical journal·2011
Same author

Single-side organically functionalized Anderson-type polyoxometalates.

Chemistry (Weinheim an der Bergstrasse, Germany)·2011
Same author

Buildup of amphiphilic molecular bola from organic-inorganic hybrid polyoxometalates and their vesicle-like supramolecular assembly.

Chemistry (Weinheim an der Bergstrasse, Germany)·2011
Same author

Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart.

Science translational medicine·2011
Same author

The epidemiological, clinical, and laboratory features of sporadic Creutzfeldt-Jakob disease patients in China: surveillance data from 2006 to 2010.

PloS one·2011

Related Experiment Video

Updated: Aug 26, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

2.9K

Combination Therapies against COVID-19.

Qunfeng Luo1, Yunxi Zheng2, Jin Zhang1

  • 1School of Basic Medical Sciences, Nanchang University, 330047 Nanchang, Jiangxi, China.

Frontiers in Bioscience (Landmark Edition)
|October 12, 2022
PubMed
Summary

This review updates progress on combination therapies for Coronavirus disease 2019 (COVID-19), focusing on small molecule treatments to combat SARS-CoV-2 and its variants.

Keywords:
anti-SARS-CoV-2anti-inflammationantiviralcombination therapycomplication

More Related Videos

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.3K
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
08:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.0K

Related Experiment Videos

Last Updated: Aug 26, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

2.9K
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.3K
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
08:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.0K

Area of Science:

  • Virology
  • Infectious Diseases
  • Pharmacology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a global pandemic with severe health and economic impacts.
  • The virus targets host cells via receptors like angiotensin converting enzyme 2, leading to diverse symptoms from fever to ARDS.
  • Existing treatments aim to disrupt viral replication or manage patient complications.

Purpose of the Study:

  • To review and update the progress of combination therapies for COVID-19.
  • To focus on treatments incorporating at least one small molecule.
  • To provide insights for developing future therapeutic strategies against SARS-CoV-2 and its variants.

Main Methods:

  • Literature review of combination therapies for COVID-19.
  • Analysis of studies involving small molecule therapeutics.
  • Synthesis of current treatment approaches and their efficacy.

Main Results:

  • Overview of various combination therapies targeting different stages of the viral life cycle.
  • Discussion of small molecule agents in combination treatment regimens.
  • Identification of promising therapeutic strategies for managing COVID-19.

Conclusions:

  • Combination therapies, particularly those with small molecules, show promise in combating COVID-19.
  • Further research into these combination strategies is crucial for developing effective treatments against current and future SARS-CoV-2 variants.