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Effect of maternal sleep on embryonic development.

Alexander Vietheer1,2, Torvid Kiserud3,4, Øystein Ariansen Haaland5

  • 1Department of Obstetrics and Gynecology, Haukeland University Hospital, Jonas Lies vei 72, 5053, Bergen, Norway. alexander.vietheer@uib.no.

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|October 12, 2022
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Summary
This summary is machine-generated.

Maternal sleep duration before pregnancy impacts early embryonic development, specifically yolk sac size and crown-rump length in male fetuses at 7 weeks. This suggests a sex- and time-dependent adaptation to sleep-related intrauterine conditions.

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Area of Science:

  • Developmental biology
  • Prenatal health
  • Maternal-fetal medicine

Background:

  • The developmental origins of health and disease (DOHaD) paradigm highlights factors influencing intrauterine development.
  • Sleep is a crucial health factor with significant individual variability, yet its role in early prenatal development is not well understood.
  • The embryonic yolk sac plays vital roles in nutrition, growth, hematopoiesis, and fetal programming.

Purpose of the Study:

  • To investigate the effect of maternal prepregnancy sleep duration on early embryonic development.
  • To assess the association between sleep duration and fetal crown-rump length (CRL) and yolk sac size.
  • To explore potential sex- and time-dependent effects on embryonic development related to maternal sleep.

Main Methods:

  • Prospective, longitudinal observational study involving 190 healthy women recruited before conception.
  • Maternal prepregnancy sleep duration was measured using actigraphy.
  • Fetal crown-rump length (CRL) and yolk sac size were assessed via ultrasound at 7 and 10 weeks of gestation.

Main Results:

  • Prepregnancy sleep duration was associated with yolk sac diameter and CRL in male fetuses at 7 weeks gestation.
  • Increased sleep duration correlated with decreased yolk sac diameter (0.22 mm·h⁻¹d⁻¹, P<0.01) and increased CRL (0.92 mm·h⁻¹d⁻¹, P=0.03).
  • No significant associations were observed at 10 weeks gestation or in female fetuses.

Conclusions:

  • Maternal sleep duration may influence early embryonic development in a sex- and time-dependent manner.
  • Findings suggest embryonic adaptation to sleep-generated differences in the intrauterine environment during normal pregnancies.
  • Further research is needed to elucidate the precise mechanisms linking maternal sleep to embryonic development.