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Related Experiment Video

Updated: Aug 26, 2025

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
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SIRT1 Activation Promotes Long-Term Functional Recovery After Subarachnoid Hemorrhage in Rats.

Dongmei Chu1,2, Xuan Li1,3, Xingguang Qu1,4

  • 1Multidisciplinary Neuroprotection Laboratories, Center for Perioperative Organ Protection, Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC, 27710, USA.

Neurocritical Care
|October 12, 2022
PubMed
Summary
This summary is machine-generated.

Resveratrol treatment improved long-term functional recovery in rats after subarachnoid hemorrhage (SAH). This SIRT1 activator enhanced neurologic scores and cognitive function, suggesting potential for SAH therapy.

Keywords:
Long-term outcomeRatsResveratrolSirtuin 1Subarachnoid hemorrhage

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Subarachnoid hemorrhage (SAH) can cause early brain injury and neurological deficits.
  • Sirtuin 1 (SIRT1) activation is known to attenuate these effects in rodent models.
  • Resveratrol is a SIRT1 activator investigated for its therapeutic potential.

Purpose of the Study:

  • To investigate the effect of resveratrol on long-term functional recovery in a rat model of SAH.
  • To determine if SIRT1 activation by resveratrol improves neurological outcomes after SAH.

Main Methods:

  • A rat model of SAH was established using arterial blood injection.
  • Rats received daily intraperitoneal injections of resveratrol (20 mg/kg) or vehicle for 7 days.
  • Functional recovery was assessed using rotarod, neurologic scoring, and Morris water maze tests.

Main Results:

  • Resveratrol treatment significantly improved neurologic scores and rotarod performance at 34 days post-SAH.
  • Morris water maze performance, measured by latency to find the platform, was significantly shortened in the resveratrol group.
  • Increased brain SIRT1 activity and improved CA1 neuronal survival were observed in resveratrol-treated rats.

Conclusions:

  • One week of resveratrol treatment significantly enhanced long-term functional recovery after SAH in rats.
  • SIRT1 activation by resveratrol shows promise as a therapeutic target for managing SAH.
  • Further investigation into SIRT1 activation for SAH therapy is warranted.