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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

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Current understanding of epigenetics role in melanoma treatment and resistance

Mohsen Karami Fath1, Ali Azargoonjahromi2, Asma Soofi3

  • 1Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.

Cancer Cell International
|October 12, 2022
PubMed

Insights

This review explores melanoma risk factors and its development, highlighting epigenetics as a key factor. Epigenetic modifications offer promising therapeutic targets for melanoma treatment and chemo-resistance.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Melanoma, an aggressive skin cancer, arises from genetic mutations in melanocytes.
  • Melanoma progression involves genetic alterations, DNA repair issues, and altered cell growth mechanisms.
  • Epigenetics plays a critical role in melanoma development and progression.

Purpose of the Study:

  • To discuss melanoma risk factors and etiopathogenesis.
  • To review the role of epigenetic pathways in melanoma progression and treatment.
  • To explore epigenetic factors as potential therapeutic solutions for melanoma and chemo-resistance.

Main Methods:

  • Literature review of melanoma risk factors.
  • Analysis of current knowledge on melanoma etiopathogenesis.
  • Detailed discussion of epigenetic pathways in melanoma progression, treatment, and chemo-resistance.

Main Results:

  • Identified key genetic and epigenetic factors contributing to melanoma development.
  • Highlighted the impact of epigenetic changes on microRNA expression and target genes.
  • Emphasized the potential of epigenetic modifications in overcoming melanoma chemo-resistance.

Conclusions:

  • Epigenetic modifications are crucial in melanoma development and progression.
  • Targeting epigenetic pathways offers novel therapeutic strategies for melanoma.
  • Epigenetic approaches show promise in addressing melanoma treatment and chemo-resistance challenges.
Keywords:
Drug resistanceEpigeneticsImmunotherapyMelanoma

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