Simulated Space Radiation Exposure Effects on Switch Task Performance in Rats

BACKGROUND: Astronauts on the mission to Mars will be subjected to galactic cosmic radiation (GCR) exposures. While ground-based studies suggest that simulated GCR (GCRsim) exposure impairs performance in multiple cognitive tasks, the impact of such exposures on task switching performance (an important skill for all aviators) has not yet been determined.METHODS: Male Wistar rats previously exposed to 10 cGy of ⁴He ions or GCRsim and their sham littermates were trained to perform a touchscreen-based switch task designed to mimic warning light response tests used to evaluate pilots' response times.RESULTS: Irradiated rats failed to complete a high cognitive task load training task threefold more frequently than shams. There were 18 (4 Sham, 7 He-, and 7 GCR-exposed) rats that successfully completed initial training and underwent switch task testing. Relative to the sham rats in the switch task, the GCRsim-exposed rats had significantly slower response times in switch but not repeat trials. The GCRsim-exposed rats had significantly (P < 0.01) higher switch response ratios (switch/repeat trial response time) and absolute switch costs (switch minus repeat trial response time) than either the sham or He-exposed rats.DISCUSSION: Rats exposed to GCRsim have significantly impaired performance in the switch task manifested as an absolute switch cost of ∼700 ms. The operational significance of such an increase requires further investigation, but a 1000-ms switch cost results in a twofold increase in cockpit error rates in pilots. If exposure to GCR in space results in similar effects in humans, the operational performance of astronauts on the Mars mission may be suboptimal.Stephenson S, Britten R.