Bovine serum albumin label-free concentration sensor based on silica corrosion quantitative monitoring system

Bovine serum albumin (BSA) label-free concentration sensor based on silica corrosion quantitative monitoring system (SCQMS) has been proposed. Anti-resonance of hollow cylindrical waveguide (HCW) in SCQMS is simulated and investigated for monitoring corrosion rate quantitatively. Hydrofluoric acid (HF) samples with different concentrations are studied respectively, and the corrosion rate is obtained by demodulating the corresponding anti-resonance dips shift and free spectral range (FSR). Therefore, a high-precision SQCMS was prepared successfully. On this basis, a highly sensitive concentration sensor based on hole-assisted dual-core fiber (HADF) is prepared. The BSA samples with concentration from 0.2 mg/mL to 0.7 mg/mL are detected. The sensor has a high sensitivity of 30.04 nm/(mg/mL) and ultra-low limit of detection (LOD) of 0.05 mg/mL for the assisted core exposed to the target solution directly. We have demonstrated the SCQMS that can be a feasible tool for precise and quantitative corrosion of silicon structure safely. In addition, the concentration sensor structure has a wide application for ultra-low LOD, simple preparation process and high integration.