Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

254
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
254
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

3.3K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.3K
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

8.5K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
8.5K
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

253
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
253
Antiepileptic Drugs: Calcium Channel Blockers01:17

Antiepileptic Drugs: Calcium Channel Blockers

559
Calcium channel blockers, a class of antiepileptic drugs, regulate the flow of calcium ions within neurons.
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
559
Non-gated Ion Channels01:24

Non-gated Ion Channels

7.0K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
7.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive analysis of the multi-rings mitochondrial genome of Populus tomentosa.

BMC genomics·2025
Same author

Evaluation of Cold Resistance in Alfalfa Varieties Based on Root Traits and Winter Survival in Horqin Sandy Land.

Biology·2025
Same author

Tryptophan metabolism-related gene CYP1B1 serves as a shared biomarker for both Parkinson's disease and insomnia.

Scientific reports·2025
Same author

A study of specific immunoglobulin G4 expression in allergic rhinitis and its value in assessing efficacy and in predicting prognosis of sublingual immunotherapy.

The Kaohsiung journal of medical sciences·2024
Same author

Non-affinity platform for processing knob-into-hole bispecific antibody.

Bioresources and bioprocessing·2024
Same author

High Relative Humidity-Induced Growth of Perovskite Nanowires from Glass toward Single-Mode Photonic Nanolasers at Sub-100-nm Scale.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2024
Same journal

Editorial.

Acta neurologica Scandinavica·2022
Same journal

Advances in sudden unexpected death in epilepsy.

Acta neurologica Scandinavica·2022
Same journal

Non-convulsive seizures and non-convulsive status epilepticus in neuro-intensive care unit.

Acta neurologica Scandinavica·2022
Same journal

Positron emission tomography in autoimmune encephalitis: Clinical implications and future directions.

Acta neurologica Scandinavica·2022
Same journal

Seizure detection based on wearable devices: A review of device, mechanism, and algorithm.

Acta neurologica Scandinavica·2022
Same journal

Walking confidence and perceived locomotion ability explain participation after stroke: A cross-sectional experimental study.

Acta neurologica Scandinavica·2022
See all related articles

Related Experiment Video

Updated: Aug 26, 2025

Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes
10:19

Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes

Published on: January 10, 2011

21.1K

Potassium channels and epilepsy.

Kai Gao1,2,3,4, Zehong Lin5, Sijia Wen1,2,3

  • 1Department of Pediatrics, Peking University First Hospital, Beijing, China.

Acta Neurologica Scandinavica
|October 13, 2022
PubMed
Summary
This summary is machine-generated.

Genetic epilepsy diagnosis is advancing with next-generation sequencing. Research in China highlights potassium channel gene mutations and precision therapies for epilepsy.

Keywords:
epilepsygenetic diagnosispotassium ion channelprecision therapy

More Related Videos

Making, Testing, and Using Potassium Ion Selective Microelectrodes in Tissue Slices of Adult Brain
11:20

Making, Testing, and Using Potassium Ion Selective Microelectrodes in Tissue Slices of Adult Brain

Published on: May 7, 2018

12.2K
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

5.0K

Related Experiment Videos

Last Updated: Aug 26, 2025

Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes
10:19

Patch Clamp and Perfusion Techniques for Studying Ion Channels Expressed in Xenopus oocytes

Published on: January 10, 2011

21.1K
Making, Testing, and Using Potassium Ion Selective Microelectrodes in Tissue Slices of Adult Brain
11:20

Making, Testing, and Using Potassium Ion Selective Microelectrodes in Tissue Slices of Adult Brain

Published on: May 7, 2018

12.2K
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

5.0K

Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • Genetic epilepsy diagnosis is increasingly accessible due to next-generation sequencing.
  • Potassium ion channels are crucial for neuronal electrical activity and implicated in epileptic seizures.
  • Research into precision therapies for genetic epilepsy is rapidly expanding.

Purpose of the Study:

  • To review the progress in precise diagnosis and treatment of potassium ion channel-related genetic epilepsy.
  • To highlight research advancements, particularly those from China.
  • To focus on specific potassium channel genes and their therapeutic targets.

Main Methods:

  • Review of recent large cohort studies on genetic epilepsy diagnosis in China.
  • Analysis of the prevalence of potassium channel gene mutations in epilepsy cohorts.
  • Examination of precision therapy progress for key potassium channel genes.

Main Results:

  • Next-generation sequencing facilitates easier and more affordable etiological diagnosis of genetic epilepsy.
  • Potassium channel genes represent a significant category of genetic epilepsy causes.
  • Several potassium channel gene targets and drug candidates for precision epilepsy therapy have been identified.

Conclusions:

  • Genetic diagnosis and precision therapy for epilepsy are rapidly advancing, especially in China.
  • Potassium ion channel gene mutations are a key focus in genetic epilepsy research.
  • Continued research is vital for developing effective precision treatments for potassium channel-related epilepsies.