Related Experiment Video
Updated: Aug 26, 2025
Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
Published on: May 20, 2016
Evaluation of aerosol drug delivery with concurrent low- and high-flow nasal oxygen
Barry Murphy1, Marc Mac Giolla Eain1, Mary Joyce1
1Research and Development, Science & Emerging Technologies, Aerogen Limited, Galway, Ireland.
Question Addressed By Study:
Administration of aerosol to patients receiving high-flow nasal oxygen (HFNO) ranges from concurrent aerosol delivery by mouthpiece to aerosol via cannula alone. This study examines the conditions to provide optimal aerosol delivery with low- or high-flow nasal oxygen with concurrent mouthpiece or through nasal cannula alone, and the impact on fugitive aerosols.
Materials And Methods:
A vibrating mesh nebuliser delivered salbutamol via mouthpiece, aerosol holding chamber and nasal cannula to an adult head model simulating relaxed breathing. The mean±sd inhaled dose (%) was assayed from a filter distal to the trachea. Optical particle sizers were used to measure fugitive aerosol concentrations during aerosol delivery.
Results:
Concurrent low-flow nasal oxygen (LFNO) and aerosol delivery with a mouthpiece and aerosol holding chamber increased the inhaled dose (%) available, 31.44±1.33% when supplemented with 2 L·min-1 of nasal oxygen. Concurrent HFNO above 30 L·min-1 resulted in a lower inhaled dose (%) compared to aerosol delivered through HFNO alone. The addition of concurrent LFNO or HFNO resulted in no increase in aerosol levels in the test room.
Answer To Question Posed:
Concurrent LFNO with a mouthpiece and aerosol holding chamber is an effective and safe means of aerosol delivery.
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