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Improvement in left ventricular diastolic function in patients with stable angina after chronic treatment with
European Heart Journal
|June 1, 1987
Summary
Calcium antagonists like verapamil and nicardipine may improve diastolic function in patients with stable angina. Verapamil demonstrated superior effects on left ventricular relaxation compared to nicardipine.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Stable angina patients may exhibit left ventricular diastolic dysfunction.
- Early detection of diastolic abnormalities is crucial before systolic dysfunction is apparent.
Purpose of the Study:
- To evaluate the effects of chronic verapamil and nicardipine therapy on left ventricular diastolic function in stable angina patients.
- To compare the efficacy of two calcium antagonists in improving diastolic indices.
Main Methods:
- A placebo-controlled, double-blind, randomized crossover study design.
- Equilibrium radionuclide angiography used to assess ventricular function.
- Automated algorithm for data analysis.
Main Results:
- Neither verapamil nor nicardipine significantly altered ejection fraction.
- Verapamil improved peak filling rate index and first one-third filling fraction more than nicardipine.
- Both drugs increased peak filling rate index, but verapamil showed greater improvements in relaxation indices.
Conclusions:
- Left ventricular relaxation abnormalities are detectable in chronic angina and may be improved by calcium antagonists.
- Verapamil offers potential advantages over nicardipine in improving diastolic function and reducing heart rate and blood pressure in these patients.
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