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Mitoxantrone hydrochloride injection for tracing helps to decrease parathyroid gland resection and increase lymph

Shaobo Chen1, Xianming Hou2, Surong Hua3

  • 1Department of Surgery, Peking Union Medical College Hospital Beijing, China.

American Journal of Cancer Research
|October 13, 2022
PubMed
Summary
This summary is machine-generated.

Mitoxantrone hydrochloride injection for tracing (MHI) significantly reduces parathyroid gland resection during thyroid cancer surgery. This novel tracer also aids pathologists in identifying more lymph nodes, improving surgical outcomes and patient safety.

Keywords:
Thyroidectomycentral lymph node dissectionmitoxantrone hydrochloride injection for tracingneck dissectionparathyroid glands

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Area of Science:

  • Oncology
  • Surgical Innovation
  • Medical Imaging

Background:

  • Preserving parathyroid glands (PGs) during thyroid surgery is critical to prevent hypoparathyroidism.
  • Current methods for identifying PGs intraoperatively have limitations.
  • Accurate lymph node staging is essential for effective thyroid cancer treatment.

Purpose of the Study:

  • To evaluate the efficacy and safety of a novel mitoxantrone hydrochloride injection for tracing (MHI) in thyroid cancer surgery.
  • To determine if MHI improves the identification and preservation of parathyroid glands.
  • To assess MHI's impact on the detection rate of central compartment lymph nodes.

Main Methods:

  • An open-label, multicenter, randomized clinical trial (CTR20171137) involving 461 patients with thyroid carcinoma.
  • Patients underwent total thyroidectomy and bilateral central compartment lymph node dissection.
  • Randomization to either the MHI group or a control group.

Main Results:

  • The parathyroid gland resection rate was significantly lower in the MHI group (6.6%) compared to the control group (26.6%) (P < 0.001).
  • MHI successfully stained central lymph nodes in 90.5%±12.0% of cases.
  • The MHI group detected more lymph nodes per patient (13.0±7.3) than the control group (10.1±6.4) (P < 0.001).
  • No adverse events related to MHI were reported.

Conclusions:

  • Mitoxantrone hydrochloride injection for tracing (MHI) is a safe and effective tracer for thyroid cancer surgery.
  • MHI significantly aids in the preservation of parathyroid glands.
  • MHI enhances the detection of central lymph nodes, potentially improving cancer staging.