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Updated: Aug 26, 2025

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins
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Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins

Published on: January 8, 2018

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Metabolite-derived protein modifications modulating oncogenic signaling

Yawen Liu1,2,3, Anke Vandekeere2,3, Min Xu1

  • 1Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, China.

Frontiers in Oncology
|October 13, 2022
PubMed

Insights

Cancer growth involves metabolic changes, tumor suppressor inactivation, and oncogene activation. These processes intricately regulate each other, influencing cellular metabolism and protein modifications crucial for malignant progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Metabolism

Background:

  • Malignant growth is characterized by metabolic rewiring, tumor suppressor inactivation, and oncogene activation.
  • These hallmarks exhibit complex regulatory crosstalk, influencing each other's functions.

Purpose of the Study:

  • To summarize the interplay between tumor suppressors/oncogenes and metabolism-induced protein modifications.
  • To explore the impact of metabolic environments on these regulatory interactions.

Main Methods:

  • Review of existing literature on cancer hallmarks and metabolism.
  • Analysis of molecular mechanisms governing crosstalk between oncogenes, tumor suppressors, and metabolic pathways.

Main Results:

  • Aberrant cellular metabolism directly impacts oncogene and tumor suppressor activity.
  • Metabolic alterations and the tumor microenvironment modulate protein modifications of oncogenes and tumor suppressors at epigenetic and post-translational levels.

Conclusions:

  • The intricate crosstalk between cellular metabolism, oncogenes, and tumor suppressors is fundamental to malignant growth.
  • Metabolic (micro)environments play a critical role in shaping these regulatory networks, offering potential therapeutic targets.
Keywords:
metabolitesoncogenic signalingpost-translational modificationtumor microenvironmenttumor suppressor gene

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