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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Natural Compounds with Oxepinochromene Scaffold. Structure, Source, Biological Activity and Synthesis
1Department of Chemistry, Faculty of Natural Sciences, University of St. Cyril and Methodius, Námestie J. Herdu 2, Trnava, Slovak Republic.
Abstract:
Natural products containing oxepinochromene motifs were first isolated from natural sources in 1960s. Natural oxepinochromenes are relatively rare and their source is limited to several endophytic and endolichenic fungi or higher plants. The importance of natural oxepinochromene derivatives lies in their promising biological activity. They exhibit a wide range of activities such as antibacterial, anticancer, anti-inflammatory or antifungal. Consequently, their synthesis has attracted significant interest. This review discusses the source, biosynthesis, biological activity, reactions as well as the total synthesis of oxepinochromene derivatives, belonging to the xanthone, terpenoid and flavone groups of phenolic secondary metabolites.
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