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A New Noninvasive Frameless Registration System for Stereotactic Cranial Biopsy: A Technical Note
Fabien Almairac1,2, Aurélie Leplus1,2, Lydiane Mondot3,4
1Neurosurgery Department, Hôpital Pasteur 2, CHU de Nice, Nice, France.
Operative Neurosurgery (Hagerstown, Md.)
|October 13, 2022
Summary
A new frameless registration tool, Neurolocate, streamlines robot-assisted brain biopsies. This noninvasive system enhances operative workflow and surgical planning efficiency for intracranial procedures.
Area of Science:
- Neurosurgery
- Medical Robotics
- Image-Guided Therapy
Background:
- Frame-based stereotactic biopsy remains a gold standard for brain biopsies.
- Frameless robot-assisted systems offer comparable safety and accuracy but often lack workflow efficiency.
Purpose of the Study:
- To introduce Neurolocate, a novel frameless, noninvasive registration tool for robot-assisted stereotactic intracranial biopsies.
- To evaluate its potential to improve the efficiency and workflow of these procedures when combined with intraoperative imaging.
Main Methods:
- Neurolocate utilizes a 3D fiducial tool with radio-opaque markers attached to the robot arm.
- A five-step procedure integrates coregistration and biopsy within a single operative session.
- Retrospective analysis of preliminary data from initial patient experiences.
Main Results:
- Twenty-three adult patients underwent biopsy using Neurolocate over one year.
- The mean operative time was 97 minutes ± 27 (SD), performed entirely in the operating room.
- The system facilitated workflow and surgical planning without invasive procedures outside the OR.
Conclusions:
- Neurolocate offers a frameless, noninvasive solution to enhance workflow and flexibility in robotic stereotactic biopsies.
- It may improve operating room management, surgical planning, and patient comfort.
- Further studies are needed to confirm its accuracy and safety profile.

