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Protocols for the social transfer of pain and analgesia in mice
Benjamin Rein1, Erin Jones2, Sabrena Tuy2
1Nancy Pritzker Laboratory, Department of Psychiatry & Behavioral Sciences, Stanford University, Palo Alto, CA 94306, USA.
Abstract:
We provide protocols for the social transfer of pain and analgesia in mice. We describe the steps to induce pain or analgesia (pain relief) in bystander mice with a 1-h social interaction with a partner injected with CFA (complete Freund's adjuvant) or CFA and morphine, respectively. We detail behavioral tests to assess pain or analgesia in the untreated bystander mice. This protocol has been validated in mice and rats and can be used for investigating mechanisms of empathy. For complete details on the use and execution of this protocol, please refer to Smith et al. (2021).
