Related Experiment Video
Updated: Aug 25, 2025

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
Published on: April 14, 2016
Premalignant Conditions of Bone
Michael D Eckhoff1, Matthew E Wells, Osvaldo Padilla
1From the Department of Orthopedics, Texas Tech University Health Science Center El Paso, El Paso, TX (Dr. Eckhoff, Dr. Wells, Dr. Thabet, and Dr. Rajani), Department of Orthopedics, William Beaumont Army Medical Center, Ft. Bliss, TX (Dr. Eckhoff, Dr. Wells, and Dr. Polfer), Department of Pathology, Texas Tech University Health Science Center El Paso, El Paso, TX (Dr. Padilla and Dr. Wilson), Paul L. Foster School of Medicine, Texas Tech University Health Science Center El Paso, El Paso, TX (Mr. Castagno), and the Department of Pathology, University of Texas Health Science Center at Houston, Houston, TX (Dr. Elzamly).
Abstract:
Development of malignancy is a multifactorial process, and there are multitude of conditions of bone that may predispose patients to malignancy. Etiologies of malignancy include benign osseous conditions, genetic predisposition, and extrinsic conditions. New-onset pain or growth in a previously stable lesion is that should concern for malignant change and should prompt a diagnostic workup for malignancy.
More Related Videos
06:00Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
Published on: September 13, 2017
06:33Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling
What is the Skeletal System?
Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
Osteoclasts in Bone Remodeling
Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...