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Updated: Aug 25, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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Role of fluid-phase complement system regulation in the development of hepatitis C virus-associated

Sara T Ibrahim1, Marwa R Abdelhamid2, Neveen Lewis3

  • 1Department of Internal Medicine and Nephrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Plos One
|October 13, 2022
PubMed

Insights

Low C4BP levels are linked to glomerulonephritis (GN) in hepatitis C virus (HCV) patients. A specific CFH gene variant (rs800292) appears protective against HCV-associated GN.

Area of Science:

  • Nephrology
  • Immunology
  • Virology

Background:

  • Hepatitis C virus (HCV) infection can lead to glomerulonephritis (GN), a kidney disease.
  • The exact mechanisms driving HCV-associated GN development in some patients remain unclear.
  • Complement system dysregulation is implicated in various kidney diseases.

Purpose of the Study:

  • To investigate the role of soluble complement regulators in the pathogenesis of HCV-associated GN.
  • To identify potential biomarkers for predicting GN development in HCV-infected individuals.

Main Methods:

  • A case-control study involving 78 participants: 26 with HCV-associated GN, 26 with HCV without GN, and 26 healthy controls.
  • Serum levels of complement regulators, including C4BP, were measured using ELISA.
  • Analysis of complement single nucleotide polymorphisms (SNPs) in C3 and CFH genes using real-time PCR.

Main Results:

  • Significantly lower serum levels of C4BP were observed in patients with HCV-associated GN compared to controls (p=0.007).
  • The minor allele (A) of the CFH gene polymorphism rs800292 was less frequent in patients with HCV-associated GN (27%) than in controls (46%) (p=0.04).

Conclusions:

  • Reduced C4BP levels are associated with the development of GN in HCV-infected patients.
  • The rs800292 SNP in the CFH gene may confer a protective effect against HCV-associated GN.
Abstract

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