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Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases
Published on: November 22, 2024
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New targets for antimalarial drug discovery
Francisco Guerra1, Elizabeth A Winzeler1
1Department of Pediatrics MC 0760, School of Medicine, University of California, La Jolla, San Diego, CA 92093, USA.
Current Opinion in Microbiology
|October 13, 2022
Summary
Phenotypic screening advanced antimalarial drug discovery, but target-based approaches are now gaining traction. This review highlights promising validated targets for developing new malaria treatments.
Area of Science:
- Medicinal Chemistry
- Parasitology
- Drug Discovery
Background:
- Phenotypic screening has identified numerous preclinical antimalarial candidates.
- The field is transitioning towards target-based drug discovery as more validated targets emerge.
Purpose of the Study:
- To review attractive, chemically validated targets for antimalarial drug discovery.
- To highlight recent advancements in identifying novel targets for malaria treatment.
Main Methods:
- Literature review of recent antimalarial drug discovery efforts.
- Analysis of chemically validated targets in malaria research.
Main Results:
- Identification of several promising targets for antimalarial drug development.
- Shift in focus from phenotypic to target-based discovery strategies.
Conclusions:
- Target-based drug discovery offers a promising avenue for novel antimalarial agents.
- Continued research into validated targets is crucial for combating malaria.
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