Post-COVID syndrome, inflammation, and diabetes
Ali A Rizvi1, Amita Kathuria1, Wael Al Mahmeed2
1Department of Medicine, University of Central Florida College of Medicine, Orlando, FL, USA.
Journal of Diabetes and Its Complications
|October 13, 2022
Summary
The COVID-19 pandemic is linked to diabetes and hyperglycemia. Long COVID may involve persistent inflammation, impacting glucose control long-term.
Area of Science:
- Endocrinology
- Infectious Diseases
- Immunology
Background:
- COVID-19 (Coronavirus Disease 2019) pandemic has caused significant global health issues.
- SARS-CoV-2 infection presents with diverse symptoms and carries high risks for vulnerable populations.
- Pathophysiology involves systemic inflammation, cardiometabolic disturbances, and glucose intolerance.
Purpose of the Study:
- To explore the relationship between COVID-19 and hyperglycemia.
- To understand the development of new-onset diabetes and worsening of existing diabetes post-COVID-19.
- To investigate the persistent symptoms and underlying mechanisms of Long COVID (Post-COVID Syndrome).
Main Methods:
- Review of existing literature on COVID-19, diabetes, and hyperglycemia.
- Analysis of pathophysiologic mechanisms linking SARS-CoV-2 infection to metabolic derangements.
- Examination of the chronic inflammatory and immunologic state in Long COVID.
Main Results:
- COVID-19 is associated with significant hyperglycemia, potentially leading to new-onset diabetes.
- Predisposing risk factors increase morbidity and mortality in SARS-CoV-2 infected individuals.
- Long COVID may stem from a persistent low-grade inflammatory and immunologic state.
Conclusions:
- Understanding COVID-related hyperglycemia and diabetes requires further research.
- Prediction, clinical course, and management strategies for COVID-related diabetes need elucidation.
- The chronic inflammatory state in Long COVID warrants continued investigation.
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