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Biology and Hemodynamics of Aneurysm Rupture
Casey A Chitwood1, Elizabeth D Shih1, Omid Amili2
1Department of Biomedical Engineering, University of Minnesota Twin Cities, 312 Church St. SE, 7-105 Nils Hasselmo Hall, Minneapolis, MN 55455, USA.
Neurosurgery Clinics of North America
|October 13, 2022
Summary
Predicting intracranial aneurysm rupture risk is crucial. This review connects hemodynamics, biology, and mechanics to understand aneurysm growth and inform predictive models for better treatment decisions.
Area of Science:
- Neurosurgery
- Vascular Surgery
- Biomedical Engineering
Background:
- Predicting rupture risk in intracranial aneurysms is a significant challenge in vascular surgery.
- Aneurysm growth is influenced by complex, multifactorial processes.
Purpose of the Study:
- To review and integrate existing literature on the factors governing intracranial aneurysm growth.
- To identify current research gaps and potential avenues for a predictive model.
Main Methods:
- Literature review synthesizing findings from hemodynamics, biology, and mechanics.
- Analysis of interdisciplinary connections between these three components.
Main Results:
- Significant progress has been made in understanding aneurysm development.
- Key factors influencing aneurysm rupture versus stability have been elucidated.
Conclusions:
- Integrating insights from hemodynamics, biology, and mechanics is essential for understanding aneurysm behavior.
- These integrated findings can inform the development of a translatable predictive model for optimizing clinical decision-making in aneurysm treatment.
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