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Complete and Partial Aortic Occlusion for the Treatment of Hemorrhagic Shock in Swine

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Valproic Acid Overdose: Case Report and Literature Review.

Jigar Patel¹, Ivan Berezowski¹, Maryann Mazer-Amirshahi²

¹Department of Emergency Medicine, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.

The Journal of Emergency Medicine

|October 13, 2022

Summary

This summary is machine-generated.

Valproic acid overdose can cause serious complications like hyperammonemic encephalopathy. L-carnitine is a key treatment, with carbapenems emerging as a potential therapy for valproic acid toxicity.

Keywords:

L-carnitine meropenem overdose toxicity valproic acid

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Area of Science:

Pharmacology
Toxicology
Emergency Medicine

Background:

Valproic acid (VPA) is a widely used antiepileptic and psychiatric medication.
VPA toxicity can lead to central nervous system depression, hyperammonemic encephalopathy, and hepatotoxicity.

Observation:

A 56-year-old male presented with intentional VPA overdose.
The patient developed hyperammonemia and was treated solely with L-carnitine.

Findings:

This case highlights the management of VPA toxicity.
Current literature suggests L-carnitine and extracorporeal removal for severe cases.
Emerging evidence supports carbapenem antibiotics, such as meropenem, in VPA toxicity management.

Implications:

Emergency physicians must be aware of VPA toxicity presentations and management options.
Prompt recognition and treatment are crucial for managing life-threatening complications.
Reviewing current literature is essential for optimizing VPA overdose treatment strategies.