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Updated: Aug 25, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
Metabolic communication in the tumour-immune microenvironment
Kung-Chi Kao1,2, Stefania Vilbois1,2, Chin-Hsien Tsai3
1Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.
Abstract:
The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating immune cells and impedes durable clinical remission following immunotherapy. Metabolic communication between cancer cells and their neighbouring immune cells could determine the amplitude and type of immune responses, highlighting a potential involvement of metabolic crosstalk in immune surveillance and escape. In this Review, we explore tumour-immune metabolic crosstalk and discuss potential nutrient-limiting strategies that favour anti-tumour immune responses.
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