Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expression and clinical diagnostic value of miR-383 in patients with severe preeclampsia.

Cellular and molecular biology (Noisy-le-Grand, France)·2020
Same author

FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway.

Oxidative medicine and cellular longevity·2020
Same author

Obesity-induced excess of 17-hydroxyprogesterone promotes hyperglycemia through activation of glucocorticoid receptor.

The Journal of clinical investigation·2020
Same author

Human neutralizing antibodies elicited by SARS-CoV-2 infection.

Nature·2020
Same author

Extensive intracranial arterial dolichoectasia involving distal branches of intracranial arteries: two cases report and review of the literature.

The International journal of neuroscience·2020
Same author

Photocaged FRET nanoflares for intracellular microRNA imaging.

Chemical communications (Cambridge, England)·2020
Same journal

Silent cerebral infarction after proximal thoracic aortic surgery under deep hypothermic circulatory arrest: an exploratory prospective DW-MRI study.

BMC cardiovascular disorders·2026
Same journal

Identifying risk individuals for heart failure diagnosis within two years in the adult population in southern Sweden using gender, age, multimorbidity level, and socioeconomic status.

BMC cardiovascular disorders·2026
Same journal

Combined associations of the metabolic score for insulin resistance and estimated glucose disposal rate with cardio-renal-metabolic multimorbidity: evidence from two large population studies.

BMC cardiovascular disorders·2026
Same journal

Elevated plasma TMAO levels associated with all-cause mortality in CAD patients in South China.

BMC cardiovascular disorders·2026
Same journal

Balloon aortic valvuloplasty for critical aortic stenosis in neonates and infants: early outcomes from a single-center cohort.

BMC cardiovascular disorders·2026
Same journal

Association between glucose-to-platelet ratio and all-cause mortality in critically ill patients with acute myocardial infarction: a retrospective cohort study.

BMC cardiovascular disorders·2026
See all related articles

Related Experiment Video

Updated: Aug 25, 2025

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

260

ALDH2 knockout protects against aortic dissection.

Chentao Luo1, Bing Zhou1, Yong Cui1

  • 1Heart Center, Department of Cardiovascular Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), 310014, Hangzhou, Zhejiang, China.

BMC Cardiovascular Disorders
|October 13, 2022
PubMed
Summary
This summary is machine-generated.

Acetaldehyde dehydrogenase 2 (ALDH2) gene knockout protects against aortic dissection by reducing inflammation and preserving aortic elastic fibers. This finding is crucial for understanding aortic dissection in Asian populations.

Keywords:
ALDH2 knockoutAorta dissectionβ-aminopropionitrile

More Related Videos

Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model
08:33

Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model

Published on: November 24, 2016

9.4K
Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease
09:06

Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease

Published on: November 28, 2012

11.0K

Related Experiment Videos

Last Updated: Aug 25, 2025

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

260
Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model
08:33

Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model

Published on: November 24, 2016

9.4K
Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease
09:06

Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease

Published on: November 28, 2012

11.0K

Area of Science:

  • Cardiovascular Research
  • Genetics
  • Immunology

Background:

  • Aortic dissection (AD) incidence and mortality are rising globally.
  • Macrophages, T lymphocytes, and dendritic cells are implicated in AD pathogenesis.
  • ALDH2 gene polymorphisms are linked to hypertension in Asians, but its role in AD is unclear.

Purpose of the Study:

  • Investigate the relationship between ALDH2 genotypes and aortic dissection incidence.
  • Explore vascular changes associated with ALDH2 in the context of aortic dissection.
  • Determine the protective effects of ALDH2 knockout on aortic dissection.

Main Methods:

  • Transverse aortic constriction (TAC) model induced by β-aminopropionitrile in mice.
  • Ultrasound imaging to assess arterial dissection and cardiac function.
  • Histological analysis (HE and EVG staining) of aortic tissues to evaluate elastic fiber integrity and pseudolumen formation.

Main Results:

  • ALDH2 knockout significantly mitigated β-aminopropionitrile-induced aortic dissection.
  • Ultrasound revealed reduced aortic widening and dissection rupture in ALDH2 knockout mice.
  • Histopathology confirmed protective effects across multiple aortic segments and decreased expression of immune cell-related genes.

Conclusions:

  • ALDH2 knockout confers protection against aortic dissection.
  • This protection is mediated by modulation of inflammatory and immune responses.
  • Preservation of aortic elastic fibers is a key mechanism underlying ALDH2's protective role.