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Metabolomic Profiles in Starved Light Breed Horses during the Refeeding Process.
Sawyer C Main1, Lindsay P Brown2, Kelly R Melvin1
1Department of Animal Science, University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA.
Animals : an Open Access Journal From MDPI
|October 14, 2022
Summary
Refeeding malnourished horses significantly alters their metabolome, impacting liver, kidney, and muscle function. This study reveals critical changes in equine metabolites during nutritional rehabilitation.
Area of Science:
- Equine Science
- Metabolomics
- Animal Nutrition
Background:
- Emaciated horses pose a significant challenge to the equine industry.
- Limited understanding of equine metabolome changes during starvation and rehabilitation.
Purpose of the Study:
- To investigate changes in equine blood chemistry and metabolome during nutritional rehabilitation.
- To understand the impact of refeeding on starved horses.
Main Methods:
- Ten emaciated horses were studied during a refeeding process.
- Blood samples analyzed using blood chemistry panels and ultrahigh performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS).
Main Results:
- Significant differences in blood chemistry and metabolite abundance were observed between the critical care and recovery periods.
- Altered levels of potentially toxic compounds, liver, kidney, muscle function analytes, and energy metabolites detected.
- Refeeding significantly impacts the equine metabolome.
Conclusions:
- Combined blood chemistry and metabolomics provide crucial biological insights into equine starvation and rehabilitation.
- The refeeding process profoundly affects the equine metabolome, highlighting its importance in recovery.
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