Related Experiment Video

Updated: Aug 25, 2025

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
07:44

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

10.2K

The Role of MARCKS in Metastasis and Treatment Resistance of Solid Tumors

Chun-Lung Chiu1, Hongjuan Zhao1, Ching-Hsien Chen2,3

  • 1Department of Urology, School of Medicine, Stanford University, Stanford, CA 94304, USA.

Cancers
|October 14, 2022
PubMed

Insights

Myristoylated alanine-rich C-kinase substrate (MARCKS) is crucial in cell functions and cancer progression. Targeting MARCKS offers a promising new therapeutic strategy for managing various cancers.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Myristoylated alanine-rich C-kinase substrate (MARCKS) is a ubiquitous, membrane-associated protein kinase C (PKC) substrate.
  • MARCKS is implicated in fundamental cellular processes such as adhesion, motility, secretion, and inflammation.
  • Dysregulated MARCKS signaling is linked to cancer development, progression, and metastasis.

Purpose of the Study:

  • To review the structure, localization, and functions of MARCKS protein.
  • To elucidate the role of MARCKS in cancer metastasis and its mechanisms in solid tumors.
  • To summarize recent advancements in targeting MARCKS for cancer therapy.

Main Methods:

  • Literature review of MARCKS protein.
  • Analysis of MARCKS's role in cancer cell migration, invasion, and stemness.
  • Evaluation of therapeutic strategies targeting MARCKS.

Main Results:

  • MARCKS regulates key cellular processes and is involved in cancer metastasis.
  • MARCKS promotes cancer cell migration, invasion, and contributes to treatment resistance.
  • Targeting MARCKS presents a potential therapeutic avenue in cancer management.

Conclusions:

  • MARCKS is a significant factor in cancer metastasis and treatment resistance.
  • Understanding MARCKS's function is vital for developing novel cancer therapies.
  • Targeting MARCKS demonstrates potential as a therapeutic strategy for cancer treatment.
Keywords:
MARCKScancer metastasiscancer stemnesstreatment resistance

More Related Videos

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior09:44

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

8.5K
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.5K

Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.7K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K