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LINC01526 Promotes Proliferation and Metastasis of Gastric Cancer by Interacting with TARBP2 to Induce GNG7 mRNA

Jin-Yong Zhou1, Jin-Yan Liu2, Yu Tao1

  • 1Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.

Cancers
|October 14, 2022
PubMed

Insights

Long noncoding RNA LINC01526 promotes gastric cancer progression by interacting with TAR RNA-binding protein 2 (TARBP2) to degrade GNG7 mRNA. This finding offers potential diagnostic and therapeutic targets for gastric cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Gastric cancer is a prevalent digestive system malignancy.
  • Long noncoding RNAs (lncRNAs) play a role in gastric cancer development.
  • The specific function of LINC01526 in gastric cancer is currently unknown.

Purpose of the Study:

  • To investigate the function and mechanism of LINC01526 in the malignant progression of gastric cancer.
  • To explore LINC01526 as a potential diagnostic biomarker and therapeutic target.

Main Methods:

  • Analysis of LINC01526 expression in gastric cancer tissues and cells.
  • In vitro functional experiments (cell proliferation and migration assays).
  • In vivo Xenograft mouse model studies.
  • Investigation of LINC01526 interaction with TAR RNA-binding protein 2 (TARBP2) and its effect on G protein gamma 7 (GNG7) mRNA stability.
  • Rescue assays to validate the mechanism.

Main Results:

  • LINC01526 expression is upregulated in gastric cancer.
  • LINC01526 promotes gastric cancer cell proliferation and migration in vitro and in vivo.
  • LINC01526 interacts with TARBP2, leading to decreased GNG7 mRNA stability.
  • Downregulation of GNG7 partially rescues the effects of LINC01526 or TARBP2 silencing on cell proliferation.

Conclusions:

  • LINC01526 promotes gastric cancer progression via the LINC01526/TARBP2/GNG7 axis.
  • LINC01526 serves as a potential biomarker and therapeutic target for gastric cancer.
Keywords:
GNG7LINC01526TARBP2gastric cancerlncRNAmRNA stability

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