Related Experiment Video

Updated: Aug 25, 2025

Isolation of Atrial Myocytes from Adult Mice
08:34

Isolation of Atrial Myocytes from Adult Mice

Published on: July 25, 2019

10.6K

The Complex Relation between Atrial Cardiomyopathy and Thrombogenesis

Elisa D'Alessandro1, Joris Winters1, Frans A van Nieuwenhoven1

  • 1Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands.

Cells
|October 14, 2022
PubMed

Insights

Atrial cardiomyopathy, linked to heart disease and metabolic issues, increases stroke risk by promoting blood clots. Activated clotting factors worsen this condition, creating a complex link between atrial issues and stroke.

Area of Science:

  • Cardiology
  • Pathophysiology
  • Biochemistry

Background:

  • Heart disease and metabolic disorders cause atrial cardiomyopathy, characterized by structural and functional myocardial changes.
  • Fibrosis, hypertrophy, and fatty infiltration in the atria contribute to atrial fibrillation (AF) vulnerability.
  • Atrial cardiomyopathy is linked to thromboembolic events, notably stroke.

Purpose of the Study:

  • To review mechanisms linking atrial cardiomyopathy to thrombogenesis.
  • To explore the impact of activated coagulation factors on atrial remodeling.
  • To elucidate the complex relationship between AF, stroke, and atrial cardiomyopathy.

Main Methods:

  • Review of existing literature on atrial cardiomyopathy, AF, and stroke.
  • Analysis of pathological mechanisms in animal models.
  • Examination of the role of coagulation factors in atrial remodeling.

Main Results:

  • Atrial cardiomyopathy promotes thrombotic events in the atria and interstitium.
  • Activated coagulation factors exert pleiotropic effects, exacerbating atrial cardiomyopathy.
  • A multidirectional causal relationship exists between atrial cardiomyopathy, hypercoagulability, and stroke.

Conclusions:

  • Atrial cardiomyopathy is a key driver of thrombogenesis, increasing stroke risk.
  • Hypercoagulability and atrial remodeling create a vicious cycle.
  • Understanding these interactions is crucial for managing AF and stroke risk.

Keywords:
atrial cardiomyopathyatrial fibrillationcardiac remodelingthrombogenesis

More Related Videos

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.8K
Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation08:56

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation

Published on: September 24, 2021

2.7K

Related Concept Videos

Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
41
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
37
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
22
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
1.0K
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
21
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
854