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Sex-Specific Effect of Obesity on Epiblepharon in Different Age Groups: A Case-Control Study

Jin-Jhe Wang1,2, Chien-Hsiung Lai1,2,3,4, Ting-Yu Kuo5

  • 1Department of Ophthalmology, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.

International Journal of Environmental Research and Public Health
|October 14, 2022
PubMed

Insights

Obesity increases epiblepharon risk in children, particularly in overweight/obese boys aged 4-9 and adolescent girls aged 13-18. This sex-specific association highlights the impact of body mass index on this ocular condition.

Area of Science:

  • Ophthalmology
  • Pediatric Health
  • Public Health

Background:

  • Obesity is a known risk factor for various ocular diseases.
  • Epiblepharon, an eyelid condition, can affect children and may be influenced by systemic factors.
  • Understanding the relationship between childhood obesity and epiblepharon is crucial for early intervention.

Purpose of the Study:

  • To investigate the age- and sex-specific association between epiblepharon and obesity in pediatric populations.
  • To determine if higher body mass index (BMI) correlates with an increased risk of epiblepharon in children.
  • To analyze the varying strength of this association across different age groups and sexes.

Main Methods:

  • A retrospective case-control study utilized the Chang Gung Research Database.
  • Identified children (≤18 years) with epiblepharon between January 1, 2009, and December 31, 2019.
  • Matched 513 patients with 1026 controls by age and sex, classifying them into normal weight, overweight, and obese groups based on BMI.

Main Results:

  • Children with epiblepharon had a significantly higher median BMI compared to controls (p < 0.001).
  • Overweight/obese boys aged 4-9 showed a significantly higher risk of epiblepharon (OR = 1.74-3.06).
  • Overweight/obese adolescent girls aged 13-18 also exhibited a statistically higher risk (OR = 3.70).

Conclusions:

  • A significant association exists between higher BMI and epiblepharon in children.
  • This relationship is age- and sex-specific, with notable risks observed in young boys and adolescent girls.
  • Findings underscore the importance of weight management in pediatric eye health.

Keywords:
body mass indexepiblepharonobesityoverweightsex-specific difference

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