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O-GlcNAcylation in Renal (Patho)Physiology.
Rodrigo P Silva-Aguiar1, Diogo B Peruchetti1, Ana Acacia S Pinheiro1,2
1Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.
International Journal of Molecular Sciences
|October 14, 2022
Summary
Protein O-GlcNAcylation, a key post-translational modification, plays a crucial role in kidney function and disease. Understanding its regulation by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) offers potential therapeutic avenues for kidney disorders.
Area of Science:
- Biochemistry
- Physiology
- Nephrology
Background:
- Kidneys maintain homeostasis through nephron structure-function correlation.
- Kidney diseases are global health issues with limited treatments.
- Altered protein O-GlcNAcylation is linked to chronic degenerative diseases.
Purpose of the Study:
- To review the impact of protein O-GlcNAcylation on kidney physiology.
- To explore the role of O-GlcNAcylation in kidney disease pathogenesis.
- To discuss future research directions in renal O-GlcNAcylation.
Main Methods:
- This review synthesizes existing literature on protein O-GlcNAcylation.
- It examines the enzymatic regulation by OGT and OGA.
- It discusses the hexosamine biosynthetic pathway's role.
Main Results:
- Protein O-GlcNAcylation is integral to normal kidney function.
- Dysregulation of O-GlcNAcylation is implicated in various kidney diseases.
- O-GlcNAcylation impacts diverse cellular functions relevant to renal health.
Conclusions:
- Protein O-GlcNAcylation is a critical factor in kidney physiology and pathology.
- Targeting O-GlcNAcylation pathways presents potential therapeutic strategies for kidney diseases.
- Further research is needed to fully elucidate O-GlcNAcylation's role in nephrology.
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