Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

3.2K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
3.2K
Renal Corpuscle01:20

Renal Corpuscle

3.1K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
3.1K
Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration01:29

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

65
The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...
65
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

56
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
56
Introduction to Urinary System01:13

Introduction to Urinary System

3.8K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
3.8K
Nephrons01:10

Nephrons

3.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preferential renal tubular injury and increased renal sympathetic activity occur during the early stages of DOCA-salt hypertension in male rats.

Physiological reports·2026
Same author

Bradykinin Contributes to Vasogenic Edema in Murine Experimental Cerebral Malaria.

bioRxiv : the preprint server for biology·2026
Same author

Angiotensin-converting enzyme 2 enhances megalin-mediated albumin endocytosis in proximal tubule cells by restraining Angiotensin II/AT1R.

The Journal of physiology·2026
Same author

Tubular Damage Biomarkers Are a Useful Tool for Identifying Early Renal Injury in Long COVID.

International journal of molecular sciences·2026
Same author

Mas-related G protein-coupled receptor type D deficiency promotes tubulointerstitial injury and fibrosis associated with proteinuria in male mice.

Physiological reports·2026
Same author

Characterization of Ceramide Kinase from Basolateral Membranes of Kidney Proximal Tubules: Kinetics, Physicochemical Requirements, and Physiological Relevance.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Aug 25, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

272

O-GlcNAcylation in Renal (Patho)Physiology.

Rodrigo P Silva-Aguiar1, Diogo B Peruchetti1, Ana Acacia S Pinheiro1,2

  • 1Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.

International Journal of Molecular Sciences
|October 14, 2022
PubMed
Summary

Protein O-GlcNAcylation, a key post-translational modification, plays a crucial role in kidney function and disease. Understanding its regulation by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) offers potential therapeutic avenues for kidney disorders.

Keywords:
O-GlcNAcO-GlcNAc transferaseO-GlcNAcaseO-GlcNAcylationalbuminuriakidneypost-translational modificationrenal disease

More Related Videos

Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

17.8K
Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
12:19

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

Published on: June 27, 2015

11.1K

Related Experiment Videos

Last Updated: Aug 25, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

272
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

17.8K
Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
12:19

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

Published on: June 27, 2015

11.1K

Area of Science:

  • Biochemistry
  • Physiology
  • Nephrology

Background:

  • Kidneys maintain homeostasis through nephron structure-function correlation.
  • Kidney diseases are global health issues with limited treatments.
  • Altered protein O-GlcNAcylation is linked to chronic degenerative diseases.

Purpose of the Study:

  • To review the impact of protein O-GlcNAcylation on kidney physiology.
  • To explore the role of O-GlcNAcylation in kidney disease pathogenesis.
  • To discuss future research directions in renal O-GlcNAcylation.

Main Methods:

  • This review synthesizes existing literature on protein O-GlcNAcylation.
  • It examines the enzymatic regulation by OGT and OGA.
  • It discusses the hexosamine biosynthetic pathway's role.

Main Results:

  • Protein O-GlcNAcylation is integral to normal kidney function.
  • Dysregulation of O-GlcNAcylation is implicated in various kidney diseases.
  • O-GlcNAcylation impacts diverse cellular functions relevant to renal health.

Conclusions:

  • Protein O-GlcNAcylation is a critical factor in kidney physiology and pathology.
  • Targeting O-GlcNAcylation pathways presents potential therapeutic strategies for kidney diseases.
  • Further research is needed to fully elucidate O-GlcNAcylation's role in nephrology.