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Genomic Mutations of the STAT5 Transcription Factor Are Associated with Human Cancer and Immune Diseases

Uijin Kim1, Ha Youn Shin1

  • 1Department of Biomedical Science and Engineering, Konkuk University, Seoul 05029, Korea.

International Journal of Molecular Sciences
|October 14, 2022
PubMed

Insights

Signal transducer and activation of transcription 5 (STAT5) plays a crucial role in development and disease. This review details STAT5

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Signal transducer and activation of transcription 5 (STAT5) is a critical transcription factor.
  • Dysregulation of STAT5 is implicated in various diseases, including cancers and immune disorders.
  • Both persistent activation and genomic mutations of STAT5 contribute to disease progression.

Purpose of the Study:

  • To comprehensively review the intrinsic functions of STAT5.
  • To elucidate the link between STAT5 mutations and human diseases.
  • To describe disease models for investigating STAT5-driven pathologies.

Main Methods:

  • Literature review of recent studies on STAT5.
  • Analysis of genomic mutations associated with STAT5.
  • Evaluation of existing and proposed disease models for STAT5 research.

Main Results:

  • STAT5 regulates key biological processes in mammalian development.
  • Aberrant STAT5 signaling and mutations are linked to solid tumors, leukemia, and other diseases.
  • Various disease models are available for studying STAT5-related mechanisms.

Conclusions:

  • Understanding STAT5 regulation is vital for comprehending disease progression.
  • Insights from this review can guide the development of improved disease models.
  • This work may inform the design of gene therapies targeting STAT5 mutations.
Keywords:
STAT5genomic mutationshuman diseasestranscriptional regulation

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