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Updated: Aug 25, 2025

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

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miR-140-5p and miR-140-3p: Key Actors in Aging-Related Diseases?

Léa Toury1, Diane Frankel2, Coraline Airault1

  • 1Aix Marseille Univ, INSERM, MMG, 13005 Marseille, France.

International Journal of Molecular Sciences
|October 14, 2022
PubMed

Insights

MicroRNAs miR-140-5p and miR-140-3p regulate genes involved in aging. Their levels in blood may predict aging diseases, highlighting their role in cellular processes like senescence and inflammation.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression by targeting mRNA.
  • The miR-140 gene produces miR-140-5p and miR-140-3p, implicated in various diseases, including cancer and aging-related conditions.
  • Dysregulated expression of miR-140-5p/-3p is observed in aging, with potential roles in disease pathophysiology.

Purpose of the Study:

  • To investigate the roles of miR-140-3p and miR-140-5p in aging-related diseases.
  • To explore the regulation of these miRNAs, including by long non-coding RNAs.
  • To review molecular targets of miR-140-5p/-3p relevant to aging pathophysiology.

Main Methods:

  • Literature review focusing on miR-140-5p and miR-140-3p.
  • Analysis of miRNA regulation mechanisms.
  • Identification and review of molecular targets involved in aging.

Main Results:

  • miR-140-5p/-3p target genes regulating cell proliferation, apoptosis, senescence, and inflammation.
  • Seric levels of miR-140-5p/-3p can serve as circulating biomarkers for aging-related diseases.
  • These miRNAs are key players in the pathophysiology of aging.

Conclusions:

  • miR-140-5p and miR-140-3p are significant regulators in aging-related diseases.
  • Their expression modulation and specific targets offer insights into aging mechanisms.
  • Circulating miR-140 levels show promise as predictive biomarkers for aging pathologies.
Keywords:
aging-related diseasesmiR-140microRNA

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