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Updated: Aug 25, 2025

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Soluble Epoxide Hydrolase Is Associated with Postprandial Anxiety Decrease in Healthy Adult Women.

Nhien Nguyen1, Christophe Morisseau2, Dongyang Li2

  • 1Department of Psychiatry, University of California San Diego, San Diego, CA 92037, USA.

International Journal of Molecular Sciences
|October 14, 2022
PubMed
Summary
This summary is machine-generated.

Soluble epoxide hydrolase (sEH) expression and activity increase after meals in women. Fasting sEH correlates with BMI and, in healthy women, impacts anxiety reduction post-meal.

Keywords:
anxietyhealthy adultsmetabolismsoluble epoxide hydrolase

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Area of Science:

  • Biochemistry
  • Human Physiology
  • Metabolic Studies

Background:

  • Soluble epoxide hydrolase (sEH) metabolizes oxylipins, impacting inflammation and disease risk.
  • The relationship between sEH and disease risk factors is not well understood.

Purpose of the Study:

  • To characterize sEH protein expression and activity in white blood cells.
  • To investigate sEH's association with metabolic factors and psychological states before and after a high-fat meal.
  • To compare these parameters between healthy women (HW) and women with anorexia nervosa (AN).

Main Methods:

  • Direct measurement of sEH protein expression and activity in white blood cells.
  • Controlled high-fat meal challenge in HW and AN participants.
  • Assessment of correlations with body mass index (BMI), age, anxiety, and depression scores.

Main Results:

  • sEH expression and activity significantly increased in both groups post-meal.
  • Fasting sEH positively associated with BMI in both groups.
  • Fasting sEH inversely associated with age in AN group (p < 0.05).
  • Higher fasting sEH correlated with a smaller decrease in anxiety post-meal in HW (p < 0.05).

Conclusions:

  • Direct measurements confirmed the link between sEH expression and in vivo activity.
  • The study elucidated sEH's role in adult women's health, particularly in response to meals and its association with BMI and anxiety.
  • sEH may be a relevant factor in metabolic health and psychological well-being in women.