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Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer

Qiuxia Wang1, Jianguo Feng2,3, Liling Tang1

  • 1Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.

International Journal of Molecular Sciences
|October 14, 2022
PubMed

Insights

Non-coding RNAs (ncRNAs) interact with the MAPK signaling pathway, influencing liver cancer development. This review explores ncRNA roles in liver cancer and discusses therapeutic strategies targeting ncRNA and MAPK signaling.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Eukaryotic cells generate numerous non-coding RNAs (ncRNAs) identified through high-throughput sequencing.
  • Certain ncRNAs are closely linked to cancer development, impacting cellular processes.
  • Mitogen-activated protein kinases (MAPK) are crucial signaling pathways regulating cell proliferation and implicated in various diseases.

Purpose of the Study:

  • To review the molecular mechanisms of non-coding RNAs (ncRNAs) involved in liver cancer.
  • To explore the association between ncRNAs and the mitogen-activated protein kinase (MAPK) signaling pathway in liver cancer.
  • To discuss potential therapeutic strategies for liver cancer targeting ncRNAs and MAPK signaling.

Main Methods:

  • Literature review of studies on non-coding RNAs (ncRNAs) and liver cancer.
  • Analysis of molecular mechanisms linking ncRNAs, including microRNA and lncRNA, to the MAPK signaling pathway.
  • Examination of current and emerging therapeutic strategies.

Main Results:

  • Non-coding RNAs (ncRNAs), such as microRNA and lncRNA, play significant roles in liver cancer development via interactions with the MAPK signaling pathway.
  • Specific ncRNAs modulate MAPK signaling, affecting cell proliferation and contributing to tumorigenesis.
  • The interplay between ncRNAs and MAPK signaling presents novel therapeutic targets for liver cancer.

Conclusions:

  • Non-coding RNAs (ncRNAs) are integral to liver cancer pathogenesis, often through their regulation of the MAPK signaling pathway.
  • Understanding these molecular interactions is key to developing targeted therapies.
  • Future research should focus on ncRNA-based and MAPK-targeted strategies for effective liver cancer treatment.
Keywords:
MAPK signaling pathwayliver cancernon-coding RNA

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