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Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer.

Qiuxia Wang1, Jianguo Feng2,3, Liling Tang1

  • 1Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.

International Journal of Molecular Sciences
|October 14, 2022
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Non-coding RNAs (ncRNAs) interact with the MAPK signaling pathway, influencing liver cancer development. This review explores ncRNA roles in liver cancer and discusses therapeutic strategies targeting ncRNA and MAPK signaling.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Eukaryotic cells generate numerous non-coding RNAs (ncRNAs) identified through high-throughput sequencing.
  • Certain ncRNAs are closely linked to cancer development, impacting cellular processes.
  • Mitogen-activated protein kinases (MAPK) are crucial signaling pathways regulating cell proliferation and implicated in various diseases.

Purpose of the Study:

  • To review the molecular mechanisms of non-coding RNAs (ncRNAs) involved in liver cancer.
  • To explore the association between ncRNAs and the mitogen-activated protein kinase (MAPK) signaling pathway in liver cancer.
  • To discuss potential therapeutic strategies for liver cancer targeting ncRNAs and MAPK signaling.

Main Methods:

  • Literature review of studies on non-coding RNAs (ncRNAs) and liver cancer.
  • Analysis of molecular mechanisms linking ncRNAs, including microRNA and lncRNA, to the MAPK signaling pathway.
  • Examination of current and emerging therapeutic strategies.

Main Results:

  • Non-coding RNAs (ncRNAs), such as microRNA and lncRNA, play significant roles in liver cancer development via interactions with the MAPK signaling pathway.
  • Specific ncRNAs modulate MAPK signaling, affecting cell proliferation and contributing to tumorigenesis.
  • The interplay between ncRNAs and MAPK signaling presents novel therapeutic targets for liver cancer.

Conclusions:

  • Non-coding RNAs (ncRNAs) are integral to liver cancer pathogenesis, often through their regulation of the MAPK signaling pathway.
  • Understanding these molecular interactions is key to developing targeted therapies.
  • Future research should focus on ncRNA-based and MAPK-targeted strategies for effective liver cancer treatment.