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Addressing Drug Resistance in Cancer: A Team Medicine Approach

Prakash Kulkarni1,2, Atish Mohanty1, Supriyo Bhattacharya3

  • 1Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.

Journal of Clinical Medicine
|October 14, 2022
PubMed

Insights

Intermittent or adaptive therapy, guided by eco-evolutionary principles and a Team Medicine approach, shows promise in overcoming cancer drug resistance. This strategy may delay resistance, reduce toxicity, and lower costs for patients.

Area of Science:

  • Oncology
  • Evolutionary Biology
  • Pharmacology

Background:

  • Drug resistance is a significant challenge in cancer treatment, leading to therapy failure.
  • Understanding the factors contributing to drug resistance is crucial for developing effective strategies.
  • Current treatment paradigms often face limitations in overcoming acquired resistance.

Purpose of the Study:

  • To explore the challenges posed by cancer drug resistance.
  • To present intermittent or adaptive therapy as a novel strategy to combat drug resistance.
  • To highlight the benefits of a collaborative, interdisciplinary approach to cancer treatment.

Main Methods:

  • Discussing the complexities of cancer drug resistance.
  • Reviewing the principles of intermittent or adaptive therapy based on eco-evolutionary concepts.
  • Emphasizing the 'Team Medicine' approach involving basic scientists and clinicians.

Main Results:

  • Intermittent or adaptive therapy has demonstrated success in delaying or preventing drug resistance in various cancers.
  • This approach can enhance the precision of personalized medicine delivery.
  • Reduced drug dosage and frequency lead to lower toxicity and fewer side effects.

Conclusions:

  • Intermittent or adaptive therapy offers a promising strategy to overcome cancer drug resistance.
  • Collaboration between researchers and clinicians is vital for advancing cancer treatment.
  • This approach has the potential to improve patient outcomes and reduce healthcare costs.
Keywords:
Team Medicineadaptive therapycontinuous therapydrug resistancedrug toleranceeco-evolutionaryintermittent therapyintrinsically disordered proteins

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