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Updated: Aug 25, 2025

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
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Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

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The Correlation of Arterial Stiffness Parameters with Aging and Comorbidity Burden

Francesco Fantin1, Anna Giani1, Monica Trentin1

  • 1Section of Geriatric Medicine, Department of Medicine, University of Verona, 37126 Verona, Italy.

Journal of Clinical Medicine
|October 14, 2022
PubMed

Insights

Arterial stiffness, measured by cardio-ankle vascular index (CAVI) and pulse wave velocity (PWV-cf), significantly correlates with aging and comorbidity burden. CAVI and CAVI0 show a stronger link to aging than PWV-cf.

Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Biomedical Engineering

Background:

  • Arterial stiffness is a key indicator of cardiovascular health.
  • Aging and comorbidity significantly impact vascular function.
  • Existing measures like pulse wave velocity (PWV-cf) and cardio-ankle vascular index (CAVI) assess arterial stiffness.

Purpose of the Study:

  • To investigate the relationships between carotid-femoral pulse wave velocity (PWV-cf), cardio-ankle vascular index (CAVI), and CAVI0 with age and comorbidity burden.
  • To identify predictors of arterial stiffness in an aging population with comorbidities.

Main Methods:

  • Cross-sectional study involving 183 patients (mean age 67.5 years) from a geriatric clinic.
  • Collected demographic, clinical, and blood analysis data.
  • Measured PWV-cf, CAVI, CAVI0, and Charlson Comorbidity Index (CCI).
  • Utilized stepwise multiple regression analysis.

Main Results:

  • Significant positive correlations were found between CAVI, CAVI0, PWV-cf, and both age and CCI (p < 0.001).
  • CCI was the sole predictor of PWV-cf in regression analysis.
  • Age and CCI were significant predictors of both CAVI and CAVI0.

Conclusions:

  • All assessed arterial stiffness indices (PWV-cf, CAVI, CAVI0) are associated with aging and comorbidity burden (CCI).
  • CAVI and CAVI0 demonstrate a stronger correlation with aging compared to PWV-cf.
  • Arterial stiffness parameters offer valuable insights into the complexity of aging individuals with significant comorbidities.

Keywords:
CAVICAVI0PWVagingcomorbidity

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