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Published on: September 3, 2020
The Development of Electroretinographic Oscillatory Potentials in Healthy Young Children
Ting Zhang1, Jinglin Lu1, Zhaoxin Jiang1
1State Key Laboratory of Ophthalmology, Retina Division, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Insights
Electroretinographic oscillatory potential (OP) responses mature significantly in children up to age 10. This study provides crucial reference data for diagnosing pediatric vision disorders using OP testing.
Area of Science:
- Ophthalmology
- Pediatric Optometry
- Neuroscience
Background:
- Electroretinography (ERG) is vital for assessing retinal function.
- Oscillatory potentials (OPs) within the ERG provide insights into inner retinal activity.
- Establishing normative data in children is essential for diagnosing visual impairments.
Purpose of the Study:
- To characterize electroretinographic oscillatory potential (OP) responses in healthy children.
- To establish age-dependent reference values for OP implicit times and amplitudes using the RETeval system.
- To provide normative data for pediatric patients undergoing vision assessments.
Main Methods:
- Recorded OP1-5 implicit times and amplitudes in 132 healthy children (0-11 years) using the RETeval system.
- Analyzed correlations between age, gender, and OP parameters.
- Determined maturation trends and time constants for OP responses.
Main Results:
- No significant gender-based differences were observed in OP implicit times or amplitudes.
- OP implicit times and amplitudes demonstrated significant maturation over the first 10 years of life.
- The majority of OP response maturation occurred within the first 4.6 years, with specific exponential time constants noted for OP1-5.
Conclusions:
- OP responses are valuable for diagnosing and evaluating vision disorders.
- The age-dependent percentiles and reference data presented are crucial for age-matched pediatric patient assessments.
- This study establishes normative OP response data for healthy children, aiding clinical interpretation.
Purpose:
This study aimed to summarize the electroretinographic oscillatory potential (OP) responses in healthy young children recorded by RETeval.
Methods:
By using the RETeval system, we recorded the implicit times and amplitudes of the OPs (OP1-5), in 132 healthy children aged from 0 to 11 years old. The age, gender, and data of implicit time and amplitude of each child were recorded and analyzed. Correlation analysis was performed between age and implicit time/amplitude.
Results:
No correlation was shown between the implicit times and amplitudes with gender. The implicit times and amplitudes of OP1-5 matured over 10 years of age, with exponential time constants of 1.9, 2.2, 1.8, 1.7, and 1.6 years and 2.1, 2.9, 2.8, 3.0, and 3.2 years, respectively. The majority of the trend occurred within the first 4.6 years.
Conclusions:
In order to diagnose and evaluate vision-related disorders, the OP response is commonly used. The percentiles and age dependence of OP responses calculated and shown in this study could be regarded as reference data in age-matched pediatric patients.
