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Interactions between ZnO Nanoparticles and Polyphenols Affect Biological Responses.

Su-Bin Kim1, Na-Kyung Yoo1, Soo-Jin Choi1

  • 1Division of Applied Food System, Major of Food Science & Technology, Seoul Women's University, Seoul 01797, Korea.

Nanomaterials (Basel, Switzerland)
|October 14, 2022
PubMed
Summary

Interactions between zinc oxide (ZnO) nanoparticles and polyphenols like quercetin increased ZnO cytotoxicity and intestinal absorption. These interactions altered nanoparticle surface chemistry but not antioxidant activity or polyphenol absorption.

Keywords:
biological responsescharacteristicsinteractionsquercetinrutinsurface chemistryzinc oxide nanoparticles

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Area of Science:

  • Food Science
  • Nanotechnology
  • Biochemistry

Background:

  • Zinc oxide (ZnO) nanoparticles are utilized as zinc supplements in functional foods.
  • Potential interactions between ZnO nanoparticles and food components necessitate investigation.
  • Understanding these interactions is crucial for food safety and efficacy.

Purpose of the Study:

  • To evaluate the impact of ZnO nanoparticle interactions with quercetin and rutin on cytotoxicity, antioxidant activity, intestinal absorption, and solubility.
  • To characterize the changes in ZnO nanoparticles and polyphenols resulting from these interactions.

Main Methods:

  • Characterization of ZnO nanoparticles and polyphenols using techniques like X-ray diffraction (XRD) and surface analysis.
  • Assessment of cytotoxicity and antioxidant activity.
  • Ex vivo evaluation of intestinal absorption and solubility.

Main Results:

  • Interactions increased ZnO nanoparticle cytotoxicity, intestinal transport, and solubility compared to pristine ZnO.
  • Antioxidant activity of polyphenols and their intestinal absorption remained unaffected.
  • Interaction effects were more pronounced with quercetin than with rutin.
  • Surface chemistry, chemical bonding, and elemental composition of ZnO nanoparticles were altered, particularly with quercetin.

Conclusions:

  • Interactions between ZnO nanoparticles and polyphenols modify their chemical characteristics and surface states.
  • These modifications lead to enhanced ZnO nanoparticle cytotoxicity, intestinal absorption, and solubility.
  • Further research is needed to fully understand the mechanisms underlying these observed effects.