Nanocone-Array-Based Platinum-Iridium Oxide Neural Microelectrodes: Structure, Electrochemistry, Durability and...

Neural interfaces provide a window for bio-signal modulation and recording with the assistance of neural microelectrodes. However, shrinking the size of electrodes results in high electrochemical impedance and low capacitance, thus limiting the stimulation/recording efficiency. In order to achieve critical stability and low power consumption, here, nanocone-shaped platinum (Pt) with an extensive surface area is proposed as an adhesive layer on a bare Pt substrate, followed by the deposition of a thin layer of iridium oxide (IrO_x) to fabricate high-performance nanocone-array-based Pt-IrO_x neural microelectrodes (200 μm in diameter). A uniform nanocone-shaped Pt with significant roughness is created via controlling the ratio of NH₄⁺ and Pt⁴⁺ ions in the electrolyte, which can be widely applicable for batch production on multichannel flexible microelectrode arrays (fMEAs) and various substrates with different dimensions. The Pt-IrO_x nanocomposite-coated microelectrode presents a significantly low impedance down to 0.72 ± 0.04 Ω cm² at 1 kHz (reduction of ~92.95%). The cathodic charge storage capacity (CSC_c) and charge injection capacity (CIC) reaches up to 52.44 ± 2.53 mC cm^-2 and 4.39 ± 0.36 mC cm^-2, respectively. Moreover, superior chronic stability and biocompatibility are also observed. The modified microelectrodes significantly enhance the adhesion of microglia, the major immune cells in the central nervous system. Therefore, such a coating strategy presents great potential for biomedical and other practical applications.