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Updated: Aug 25, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Current Progress in the Chemoenzymatic Synthesis of Natural Products
Evan P Vanable1, Laurel G Habgood2, James D Patrone2
1Department of Chemistry and Biochemistry, Elmhurst University, Elmhurst, IL 60126, USA.
Abstract:
Natural products, with their array of structural complexity, diversity, and biological activity, have inspired generations of chemists and driven the advancement of techniques in their total syntheses. The field of natural product synthesis continuously evolves through the development of methodologies to improve stereoselectivity, yield, scalability, substrate scope, late-stage functionalization, and/or enable novel reactions. One of the more interesting and unique techniques to emerge in the last thirty years is the use of chemoenzymatic reactions in the synthesis of natural products. This review highlights some of the recent examples and progress in the chemoenzymatic synthesis of natural products from 2019-2022.
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