A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA

Area of Science:

• Materials Science
• Analytical Chemistry
• Biomarker Detection

Background:

• Thiodiglycolic acid (TDGA) is a critical biomarker for monitoring vinyl chloride exposure.
• Accurate and rapid quantification of TDGA is essential for health assessments.

Purpose of the Study:

• To develop a facile, rapid, and precise fluorescent sensor for TDGA detection.
• To synthesize and characterize a novel dual-emissive UiO-66 based material for ratiometric sensing.

Main Methods:

• Synthesis of a ratiometric fluorescent material, C460@Tb-UiO-66-(COOH)2, by incorporating 7-diethylamino-4-methylcoumarin (C460) and Tb3+ into UiO-66-(COOH)2.
• Utilizing the material for selective and sensitive detection of TDGA.
• Investigating the fluorescence quenching mechanism induced by TDGA.

Main Results:

• The C460@Tb-UiO-66-(COOH)2 sensor exhibited high selectivity, anti-interference, and rapid response for TDGA.
• Achieved a low detection limit of 0.518 mg·mL-1 for TDGA, significantly below the healthy threshold of 20 mg·mL-1.
• Detailed analysis of the fluorescence quenching mechanism was provided.

Conclusions:

• The developed ratiometric fluorescent sensor demonstrates excellent performance for TDGA detection.
• This sensor holds promise for the quantitative analysis of TDGA in human urine samples.
• The findings contribute to improved monitoring of vinyl chloride exposure.