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Natural and Synthetic Polymer Scaffolds Comprising Upconversion Nanoparticles as a Bioimaging Platform for Tissue
Ekaterina M Trifanova1, Maria A Khvorostina1, Aleksandra O Mariyanats1
1Institute of Photon Technologies of Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, 108840 Moscow, Russia.
Molecules (Basel, Switzerland)
|October 14, 2022
Summary
This study presents smart scaffolds for tissue engineering, integrating upconversion nanoparticles (UCNPs) into biocompatible polymers for real-time monitoring and controlled interactions. These novel constructs enhance cell growth and material stability for guided tissue regeneration.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Biocompatible materials are crucial for tissue engineering constructs (TECs) used in regenerative medicine.
- Advanced processing techniques enable the creation of functionalized scaffolds for guided tissue regeneration.
Purpose of the Study:
- To develop novel TECs using electrospinning and 3D printing with upconversion nanoparticles (UCNPs).
- To enable in vitro control of tissue/scaffold interactions and real-time monitoring via photoluminescence.
Main Methods:
- Fabrication of TECs using polylactic-co-glycolic acids (PLGA), collagen (COL), and hyaluronic acid (HA).
- Impregnation of scaffolds with core/shell β-NaYF4:Yb3+,Er3+/NaYF4 UCNPs.
- Visualization using 976 nm laser irradiation and analysis of photoluminescence spectra.
Main Results:
- UCNP-impregnated scaffolds exhibited distinct photoluminescence spectra for microenvironment control.
- Demonstrated absence of cytotoxicity and high efficiency in cell attachment, proliferation, and colonization.
- Enhanced tensile strength and structural stability of COL-based scaffolds.
Conclusions:
- Developed a technological platform for "smart scaffolds" using UCNP-impregnated bioresorbable polymers.
- Achieved desired photoluminescent, biochemical, and mechanical properties for intravital monitoring.
- Enabled real-time visualization and assessment of tissue/scaffold interactions.
