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A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
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NIR-II AIEgens with Photodynamic Effect for Advanced Theranostics.

Shuai Yin1,2, Jianwen Song2, Dongfang Liu2,3

  • 1School of Pharmacy, Nantong University, Nantong 226001, China.

Molecules (Basel, Switzerland)
|October 14, 2022
PubMed
Summary

Aggregation-induced emission luminogens emitting in the second near-infrared window (NIR-II) are advancing photodynamic therapy (PDT) and imaging. These NIR-II AIEgens offer enhanced tumor visualization and treatment efficacy for precision medicine.

Keywords:
NIR-IIaggregation-induced emissionbiomedical applicationphotodynamicphototheranosticprecision medicine

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Phototheranostics integrate diagnosis and therapy for personalized medicine.
  • The second near-infrared window (NIR-II) offers deep tissue penetration and high resolution for imaging.
  • NIR-II agents with photodynamic therapy (PDT) properties are crucial for advanced phototheranostics.

Purpose of the Study:

  • To review recent advancements in photodynamic NIR-II aggregation-induced emission luminogens (AIEgens).
  • To discuss molecular design strategies for tuning AIEgens' photophysical properties.
  • To highlight biomedical applications of NIR-II AIEgens in image-guided therapy and multifunctional theranostics.

Main Methods:

  • Literature review of recent research on NIR-II AIEgens.
  • Analysis of molecular design principles for optimizing photophysical properties.
  • Summarization of biomedical applications, including tumor therapy and bacterial infection treatment.

Main Results:

  • NIR-II AIEgens demonstrate significant potential for enhanced fluorescence and photoacoustic imaging.
  • These agents enable effective image-guided photodynamic therapy for various tumor models.
  • Multifunctional theranostics combining NIR-II AIEgens with chemotherapy and immunotherapy show promising results.

Conclusions:

  • NIR-II AIEgens are powerful tools for improving photodynamic therapy and imaging precision.
  • Understanding the structure-property-application relationship is key for developing advanced long-wavelength emitting PDT agents.
  • These luminogens hold great promise for accelerating personalized and precision medicine through enhanced theranostic outcomes.