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Updated: Aug 25, 2025

A Protocol for Detecting and Scavenging Gas-phase Free Radicals in Mainstream Cigarette Smoke
Published on: January 2, 2012
A New 1,3-Benzodioxole Compound from Hypecoum erectum and Its Antioxidant Activity
Ning Xu1, Wenli Bao1, Jiletu Xin1
1Inner Mongolia Key Laboratory of the Natural Products Chemistry and Functional Molecular Synthesis, Inner Mongolia Minzu University, Tongliao 028000, China.
Abstract:
The purpose of this study was to identify the chemical components in aerial parts of Hypecoum erectum. A new 1,3-benzodioxole derivative, identified as Hypecoumic acid (1), was isolated, together with the three known compounds: protopine (2), coptisine (3), and cryptopine (4). Their structures were identified based on extensive spectroscopic experiments, including nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectra (HR-ESI-MS), as well as comparison with those reported in the literature. Meanwhile, the in vitro antioxidative activity of all compounds was determined using a DPPH-scavenging assay, and compound 1 (IC50 = 86.3 ± 0.2 μM) was shown to have moderate antioxidative activity.
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