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Updated: Aug 25, 2025

Assaying Proteasomal Degradation in a Cell-free System in Plants
Published on: March 26, 2014
The Ubiquitin-Proteasome System (UPS) and Viral Infection in Plants
Dania P Lobaina1,2, Roberto Tarazi1,2, Tamara Castorino1
1Laboratório de Virologia Molecular Vegetal, Departamento de Virologia IMPPG, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, RJ, Brazil.
Abstract:
The ubiquitin-proteasome system (UPS) is crucial in maintaining cellular physiological balance. The UPS performs quality control and degrades proteins that have already fulfilled their regulatory purpose. The UPS is essential for cellular and organic homeostasis, and its functions regulate DNA repair, gene transcription, protein activation, and receptor trafficking. Besides that, the UPS protects cellular immunity and acts on the host's defense system. In order to produce successful infections, viruses frequently need to manipulate the UPS to maintain the proper level of viral proteins and hijack defense mechanisms. This review highlights and updates the mechanisms and strategies used by plant viruses to subvert the defenses of their hosts. Proteins involved in these mechanisms are important clues for biotechnological approaches in viral resistance.
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