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Vitamin D in Systemic Sclerosis: A Review.

Mattia Perazzi1,2, Enrico Gallina1,2, Giulia Francesca Manfredi1,2

  • 1Department of Translational Medicine (DIMET), Università del Piemonte Orientale UPO, Via Solaroli 17, 28100 Novara, Italy.

Nutrients
|October 14, 2022
PubMed
Summary

Vitamin D may help reduce fibrosis in systemic sclerosis (SSc), but more clinical research is needed. Low vitamin D levels are common in SSc patients and treating this deficiency can prevent osteoporosis.

Keywords:
cholecalciferolsystemic sclerosisvitamin D

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Area of Science:

  • Rheumatology
  • Endocrinology
  • Dermatology

Background:

  • Systemic sclerosis (SSc) is a complex autoimmune disease.
  • The role of vitamin D in SSc pathogenesis and treatment requires further investigation.

Purpose of the Study:

  • To review existing evidence on vitamin D's role in systemic sclerosis.
  • To evaluate vitamin D's potential in SSc management and its association with disease characteristics.

Main Methods:

  • Comprehensive literature review of PubMed, Medline, Embase, and Cochrane databases.
  • Inclusion of various study designs: cohort, case-control, RCTs, and observational studies.
  • Keywords: "vitamin D", "cholecalciferol", "systemic sclerosis", "scleroderma".

Main Results:

  • Nine pre-clinical and 21 clinical studies were identified.
  • Pre-clinical data suggest vitamin D analogs may inhibit fibrogenesis.
  • Clinical studies consistently show high prevalence of vitamin D deficiency and osteoporosis in SSc patients.

Conclusions:

  • In vitro studies indicate a potential antifibrotic effect of vitamin D in SSc.
  • Clinical evidence supporting vitamin D's antifibrotic role in SSc is currently limited.
  • Vitamin D deficiency is prevalent in SSc and treating it is crucial for preventing osteoporosis.